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Tuesday, March 31 • 10:25am - 10:40am
Megan Sweeney: βTRCP: Linking Circadian Rhythms and Metabolism

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Shifts in circadian rhythms, like in shift work or jetlag, have been shown to increase the risk of many metabolic disorders. Therefore, it is not surprising that many genes involved in the circadian clock mechanism have demonstrated a regulatory role in metabolism. It has been shown that E3 ubiquitin ligases can influence metabolism as well. In our initial studies, we created a knockout of two E3 ubiquitin ligases thought to be essential to the clock, βTRCP1/2, in a mouse model in order to study the proteasomal degradation machinery in mammals. Upon characterizing the circadian phenotype of this mouse, we noticed an unprecedented, metabolic phenotype after deletion of these vital ligases. These novel mutant mice lose over 30% of their body weight within 5 days while still maintaining an eating and drinking regime similar to wild-type mice. In this project, in vitro and in vivo studies aimed to look further into the causes of this phenomenon and the molecular mechanisms underlying them.


Tuesday March 31, 2015 10:25am - 10:40am EDT
Civic Center - Meeting Room C - Ground Floor 505 West Pensacola Street, Tallahassee, FL 32301

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